Findings from our studies include the detection of SV40 neutralizing antibodies in various population groups the fecal excretion of polyomaviruses by humans, indicating a probable fecal–oral route of transmission the detection of SV40 in normal and malignant lymphoid-rich tissues, suggesting that lymphoid cells are important in the pathogenesis of SV40 infections and the variable frequency of SV40-positive lymphomas in two urban populations, emphasizing that SV40 infection and disease likely reflect population differences. Authentic SV40 can cause human infections.
Both viral genetic variation and route of inoculation influence host antibody responses to viral proteins. As there was no effect on transforming activity in vitro, strain-specific factors must affect virus–host interactions that are not detectable using cultured cells. Other findings include the significant effect of the structure of the viral regulatory region on both oncogenic potential and vertical transmission in vivo. Viral microRNA reduced viral DNA levels in infected tissues and may contribute to the establishment of persistent infections. Recent results from the hamster model identified broad tissue tropism for SV40 and provided the first evidence of expression and function of SV40 microRNA in vivo.
We have developed the Syrian golden hamster small animal model to study SV40 pathogenesis of infection and disease. We have identified rare variants of polyomaviruses, recovered from immunosuppressed hosts, that have lost the ability to express viral microRNAs. Sequence analysis of viral isolates has revealed differences in the structure of the noncoding viral regulatory region as well as the existence of a variable region at the C-terminus of T-ag that can classify SV40 strains into genogroups. It is a complex protein that possesses multiple functions important for replicating the viral DNA and for dysregulating cell cycle control. The large tumor antigen (T-ag) of SV40 is the major transforming protein of the virus, responsible for tumor causation in hamsters and transformation of many cell types in culture. As a model tumor virus, SV40 has provided many fundamental insights into the molecular basis of carcinogenesis. Originally isolated from monkeys, SV40 is a small DNA virus that is able to transform cells in culture and induce tumors in hamsters. Polyomavirus Pathogenesis of Infections and Disease The Butel laboratory studies the biology and molecular biology of the polyomaviruses, with a primary focus on polyomavirus SV40. Honoree, Hearts of Gold: Honoring Women in Health & Medical Science Gala, The Harris County Medical Society and The Health Museum Kyle and Josephine Morrow Chair in Molecular Virology and Microbiology, Baylor College of Medicine Cancer Research–Women in Cancer Research–Charlotte Friend Memorial Lecture Press)Ģ002 Distinguished Alumnus, Graduate School of Biomedical Sciences Award, Baylor College of Medicine Included in “Women Pioneers in Texas Medicine” (Silverthorne and Fulgham, Texas A&M Univ. Melnick Professor of Virology, Baylor College of Medicineįellow, American Association for the Advancement of Scienceĭistinguished Service Professor, Baylor College of Medicine Sigma Xi Research Award for Excellence in ResearchĪmerican Cancer Society Faculty Research Award
National Science Foundation Graduate Fellowships
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